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Oxymorphone is a potent opioid pain reliever used to treat moderate to severe pain, especially in patients who require long-term, around-the-clock pain management. It works by binding to opioid receptors in the brain and spinal cord, altering the body's perception of pain. Opana is available in both immediate-release (IR) and extended-release (ER) formulations, with the latter designed for chronic pain management.

Due to its high potency, Opana carries a significant risk of dependence, addiction, and misuse, similar to other strong opioids. Common side effects include drowsiness, dizziness, nausea, vomiting, constipation, dry mouth, and sweating. More serious risks include respiratory depression, low blood pressure, and overdose, especially when combined with alcohol, benzodiazepines, or other central nervous system depressants.

In 2017, the extended-release (ER) version of Opana was voluntarily withdrawn from the market in the U.S.